Hepatic Injury Caused by L -Alpha-Methyldopa

Hepatic injury caused by L-alpha-methyldopa.

a rise in serum alkaline phosphatase, glutamic oxaloacetic transaminase levels, and increased Bromsulphalein retention. Elevation of the serum bilirubin may occur. In its most benign form the condition is usually symptomless, but complaints, such as anorexia, abdominal pain, or pruritus, and signs, such as fever or hepatomegaly, may occur. Histologic changes similar to those of viral hepatitis ...

Hepatic injury caused by mianserin.

Alpha-methyldopa hepatotoxicity in pregnancy.

A 12-week pregnant, 33-year-old African American female, presented with jaundice and change in urine colour. Liver function tests revealed raised transamines and normal alkaline phosphatase. She was started on methyldopa 6 weeks prior to presentation. After initial negative investigations including viral and autoimmune hepatitis, she was given prednisone for methyldopa induced hepatitis. Two we...

Enzyme Activities during Hepatic Injury Caused by Carbon Tetrachloride.

Rats injected with carbon tetrachloride show markedly elevated plasma glutamic oxalacetic transaminase and plasma fumarase but, at the same time, these enzyme activities do not decrease in the liver. Three mechanisms are proposed which may account for the increase in plasma enzymes: first, a transfer of the enzyme systems from the necrotized liver cell to the plasma; second, the synthesis of pl...

Bronchial asthma due to alpha-methyldopa.

iron-storage disease, malignant disease, and a history of neck surgery or irradiation. Bone biopsy was not performed in either case because of the absence of any biochemical or radiological evidence of osteomalacia. Our first case is the oldest known patient to present with this disorder, the oldest described elsewhere being an 80-year-old man who presented with confusion.4 Little is known abou...